| http://purl.uniprot.org/citations/30808808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30808808 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC-I epitope presentation to CD8+ T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases underlying peptide selection and binding by MHC-I remain largely unknown. Within the peptide-loading complex, the peptide editor tapasin is key to the selection of MHC-I-bound peptides. Here, we have determined an ensemble of crystal structures of MHC-I in complex with the peptide exchange-associated dipeptide GL, as well as the tapasin-associated scoop loop, alone or in combination with candidate epitopes. These results combined with mutation analyses allow us to propose a molecular model underlying MHC-I peptide selection by tapasin. The N termini of bound peptides most probably bind first in the N-terminal and middle region of the MHC-I peptide binding cleft, upon which the peptide C termini are tested for their capacity to dislodge the tapasin scoop loop from the F pocket of the MHC-I cleft. Our results also indicate important differences in peptide selection between different MHC-I alleles."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1807656116"xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Achour A."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Sun R."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Sandalova T."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Duru A.D."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Hafstrand I."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Josey B.J."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Nygren P.A."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Pellegrino S."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Janssen L."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Georgoudaki A.M."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Nilvebrant J."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Ozkazanc D."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Apavaloaei A."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Potens R."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/author | "Sayitoglu E.C."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/pages | "5055-5060"xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/title | "Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin."xsd:string |
| http://purl.uniprot.org/citations/30808808 | http://purl.uniprot.org/core/volume | "116"xsd:string |