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http://purl.uniprot.org/citations/30809535http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30809535http://www.w3.org/2000/01/rdf-schema#comment"

Aim

Vitamin D plays an important role in water and salt homeostasis. The aim of our study was to investigate the underlying relationship of Vitamin D and Aquaporins (AQP).

Methods

The behaviors of 1α (OH)-ase knockout mice and wild type mice were observed before analysis. The ICR mice were treated with vehicle or paricalcitol, a vitamin D analogue, followed by animals receiving a standard diet and free access to drinking water either with aliskiren (renin blocker; 37.5 mg aliskiren in 100 ml water), or telmisartan (a angiotensin II type I receptor blocker; 40 mg telmisartan in 100 ml water) a week before study. The expressions of AQP-1, AQP-4, and renin in mice kidneys were detected by western bolting, immunohistochemistry, and immunofluorescence.

Results

Diuresis and polydipsia were observed in 1α (OH)-ase knockout mice, and a decreased water intake and urine output in ICR mice was observed after paricalcitol treatment. Compared with wild type, the AQP-1 expressions were increased in renal papilla and AQP-4 expressions were decreased in renal proximal tubule of 1α(OH) ase knockout mice. In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. After injecting renin into the lateral ventricle of the 1α(OH)ase knockout mice, the renin expression level was decreased in the kidney, followed by the decrease of AQP-1 in renal papilla and increase of AQP-4 in proximal tubule.

Conclusions

Overall, Vitamin D and renin inhibitors have synergistic effects in regulating water channels in mice kidneys."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.org/dc/terms/identifier"doi:10.1155/2019/3027036"xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Fu Y."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Zhu J."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Su H."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/author"Kong J."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/name"Biomed Res Int"xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/pages"3027036"xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/title"Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys."xsd:string
http://purl.uniprot.org/citations/30809535http://purl.uniprot.org/core/volume"2019"xsd:string
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