| http://purl.uniprot.org/citations/30811870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30811870 | http://www.w3.org/2000/01/rdf-schema#comment | "Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mechanism of SOX2-OT in LSCC remains unclear. In this study, we found that SOX2-OT expression was increased and negatively correlated with PTEN expression in LSCC tissues. Furthermore, SOX2-OT overexpression promoted LSCC cell proliferation, migration, invasion, and suppressed cell apoptosis in vitro, as well as facilitated the in vivo tumorigenicity. By contrast, SOX2-OT silencing exerted the opposite effect. Mechanically, SOX2-OT interacted with EZH2 and recruited EZH2 to induce H3K27me3 and epigenetically inhibited PTEN expression in LSCC cells. Additionally, EZH2 silencing and PTEN overexpression significantly abrogated the SOX2-OT overexpression-mediated promotion of LSCC cell malignant behavior. Collectively, our findings demonstrate that SOX2-OT inhibits PTEN expression to facilitate LSCC development through EZH2-mediated H3K27me3. © 2019 IUBMB Life, 71(9):1230-1239, 2019."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.org/dc/terms/identifier | "doi:10.1002/iub.2026"xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Ji Y."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Zang Y."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/author | "Tai Y."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/name | "IUBMB Life"xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/pages | "1230-1239"xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/title | "Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma development by epigenetically inhibiting PTEN via methyltransferase EZH2."xsd:string |
| http://purl.uniprot.org/citations/30811870 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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