| http://purl.uniprot.org/citations/30827887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30827887 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant prostate cancer (PCa), for which there is no effective therapy. Here we report that protein kinase C (PKC)λ/ι is downregulated in de novo and during therapy-induced NEPC, which results in the upregulation of serine biosynthesis through an mTORC1/ATF4-driven pathway. This metabolic reprogramming supports cell proliferation and increases intracellular S-adenosyl methionine (SAM) levels to feed epigenetic changes that favor the development of NEPC characteristics. Altogether, we have uncovered a metabolic vulnerability triggered by PKCλ/ι deficiency in NEPC, which offers potentially actionable targets to prevent therapy resistance in PCa."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2019.01.018"xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Scott D.A."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Cordes T."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Eng K."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Duran A."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Richards A."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Metallo C.M."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Beltran H."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Garcia-Olmo D.C."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Salinas-Sanchez A.S."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Linares J.F."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Reina-Campos M."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "L'Hermitte A."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Nam-Cha S.Y."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Badur M.G."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Bhangoo M.S."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Rooslid T."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/author | "Thorson P.K."xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/30827887 | http://purl.uniprot.org/core/pages | "385-400.e9"xsd:string |