| http://purl.uniprot.org/citations/30827889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30827889 | http://www.w3.org/2000/01/rdf-schema#comment | "Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. Blocking Y240 phosphorylation confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240F-Pten knockin mice showed radiation sensitivity. These results suggest that FGFR-mediated pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for improving radiotherapy efficacy."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2019.01.020"xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Koga T."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Kolodner R.D."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Boyer A."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Varki N.M."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Sulman E.P."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Fenton T.R."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Reed R."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Miki S."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Cavenee W.K."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Shiau A.K."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Lindahl E."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Furnari F.B."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Benitez J.A."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "DeGroot J."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Orellana L."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Zanca C."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Gahman T.C."xsd:string |
| http://purl.uniprot.org/citations/30827889 | http://purl.uniprot.org/core/author | "Nagahashi Marie S.K."xsd:string |