| http://purl.uniprot.org/citations/30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30851935 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously confirmed that Nuclear factor erythroid 2-related factor-2 (Nrf2) and heme oxygenase (HO-1) play synergistic roles in the pathogenesis of preeclampsia. To further explore the function of HO-1 in the pathogenesis of preeclampsia, we established oxidative stress models respectively with human first-trimester trophoblast/simian virus (HTR8/SVneo) and human umbilical vein endothelial cells (HUVECs) and then assessed the effect of HO-1 on the two cell lines in oxidative stress conditions. The cell oxidative stress models were incubated with Hemin (an inducer of HO-1), then, the HTR8/SVneo cells were transfected by ZO-1 small interfering RNA (siRNA). The HTR-8/SVneo invasive abilities were detected, and the tube formation abilities of HUVECs were measured. HO-1 and tight junction proteins zonula occludens-1 (ZO-1) and occludin in the cells were detected. In both the trophoblastic and HUVEC oxidative stress models, HO-1、ZO-1 and occludin were increased incubated with Hemin. Meanwhile, HTR-8/SVneo cells incubated with Hemin showed increased invasion function against the destruction of hydrogen peroxide (H2O2). Similarly, the tube formation ability of HUVECs incubated with Hemin was increased. The above-mentioned effects were disappeared after HTR-8/SVneo cells were transfected by ZO-1 siRNA. These results suggest that HO-1 protects the function of placental cells in oxidative stress via regulating ZO-1/occludin."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.02.144"xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Tian B."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Chu Y."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/pages | "903-909"xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/title | "Activation of HO-1 protects placental cells function in oxidative stress via regulating ZO-1/occludin."xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://purl.uniprot.org/core/volume | "511"xsd:string |
| http://purl.uniprot.org/citations/30851935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30851935 |
| http://purl.uniprot.org/citations/30851935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30851935 |
| http://purl.uniprot.org/uniprot/#_A0A087X0K9-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_F2YMD9-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_D2K7W4-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_A8K3T2-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_B2R7U4-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_B4DZK4-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |
| http://purl.uniprot.org/uniprot/#_A9CQZ8-mappedCitation-30851935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30851935 |