| http://purl.uniprot.org/citations/30852906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30852906 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundRecovery of the interstitial cells of Cajal (ICCs) during post-operative ileus (POI) is important for the restoration of gastrointestinal (GI) motility. Acupuncture can protect ICCs, but the underlying mechanisms remain unclear. In this study, we investigated whether miR-222, c-kit and endothelial nitric oxide synthase (eNOS) are involved in the putative effects of acupuncture on ICC recovery.MethodsA POI model was established in Sprague-Dawley rats by colo-colic anastomosis, and then acupuncture was performed at bilateral ST36, SP6 and LR3 once daily for 3 consecutive days. C-kit protein expression in the colonic tissue adjacent to the incision site was determined by immunohistochemistry and Western blotting. mRNA levels of c-kit, eNOS and miR-222 were measured by real-time polymerase chain reaction (RT-PCR).ResultsThe levels of c-kit mRNA/protein and eNOS mRNA decreased, while miR-222 increased in the colonic tissues of POI model rats. Acupuncture treatment improved GI motility, inhibited the up-regulation of miR-222 and blocked the down-regulation of c-kit mRNA/protein and eNOS mRNA. The levels of miR-222 and c-kit were negatively correlated.ConclusionAcupuncture at ST36, SP6 and LR3 facilitates ICC recovery and improves post-operative GI motility in part through regulation of miR-222, c-kit and eNOS."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.org/dc/terms/identifier | "doi:10.1177/0964528419829755"xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/author | "Yuan Q."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/author | "Lai M.Y."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/author | "Deng J.J."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/name | "Acupunct Med"xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/pages | "125-132"xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/title | "Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus."xsd:string |
| http://purl.uniprot.org/citations/30852906 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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