| http://purl.uniprot.org/citations/30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30853411 | http://www.w3.org/2000/01/rdf-schema#comment | "The Dedicator Of CytoKinesis (DOCK) family of atypical guanine nucleotide exchange factors activates the Rho family GTPases Rac and/or Cdc42 through DOCK homology region 2 (DHR-2). Previous structural analyses of the DHR-2 domains of DOCK2 and DOCK9 have shown that they preferentially bind Rac1 and Cdc42, respectively; however, the molecular mechanism by which DHR-2 distinguishes between these GTPases is unclear. Here we report the crystal structure of the Cdc42-bound form of the DOCK7 DHR-2 domain showing dual specificity for Rac1 and Cdc42. The structure revealed increased substrate tolerance of DOCK7 at the interfaces with switch 1 and residue 56 of Cdc42. Furthermore, molecular dynamics simulations showed a closed-to-open conformational change in the DOCK7 DHR-2 domain between the Cdc42- and Rac1-bound states by lobe B displacement. Our results suggest that lobe B acts as a sensor for identifying different switch 1 conformations and explain how DOCK7 recognizes both Rac1 and Cdc42."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2019.02.001"xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Ihara K."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Shirouzu M."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Tsuda K."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Ohsawa N."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Kukimoto-Niino M."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/author | "Mishima-Tsumagari C."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/pages | "741-748.e3"xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/title | "Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor."xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/30853411 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30853411 |
| http://purl.uniprot.org/citations/30853411 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30853411 |
| http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_Q07890-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_Q14155-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_Q14185-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_A1L390-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |
| http://purl.uniprot.org/uniprot/#_A4FU72-mappedCitation-30853411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853411 |