| http://purl.uniprot.org/citations/30853823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30853823 | http://www.w3.org/2000/01/rdf-schema#comment | "14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.org/dc/terms/identifier | "doi:10.5607/en.2019.28.1.43"xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Park J.Y."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Kim H.W."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Kwon O."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Cho C.H."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Hwang E.M."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Kim D.E."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/author | "Sim K.M."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/name | "Exp Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/pages | "43-53"xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/title | "14-3-3gamma Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors."xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/30853823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30853823 |
| http://purl.uniprot.org/citations/30853823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30853823 |
| http://purl.uniprot.org/uniprot/#_A8IP69-mappedCitation-30853823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853823 |
| http://purl.uniprot.org/uniprot/#_P61982-mappedCitation-30853823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853823 |
| http://purl.uniprot.org/uniprot/#_Q3TP56-mappedCitation-30853823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30853823 |
| http://purl.uniprot.org/uniprot/P61982 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30853823 |
| http://purl.uniprot.org/uniprot/Q3TP56 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30853823 |
| http://purl.uniprot.org/uniprot/A8IP69 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30853823 |