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http://purl.uniprot.org/citations/30854931http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30854931http://www.w3.org/2000/01/rdf-schema#comment"

Purpose/objectives

We aimed to assess the predictive value of a lung cancer gene panel for the development of brain metastases.

Materials/methods

Between 2011 and 2015, 102 patients with lung cancer were prospectively enrolled in a clinical trial in which a diagnostic fine-needle aspirate was obtained. Gene expression was conducted on all samples that rendered a diagnosis of non-small cell lung cancer (NSCLC). Subsequent retrospective analysis of brain metastases-related outcomes was performed by reviewing patient electronic medical records. A competing risk multivariable regression was performed to estimate the adjusted hazard ratio for the development of brain metastases and non-brain metastases from NSCLC.

Results

A total of 49 of 102 patients had died by the last follow-up. Median time of follow-up was 13 months (range 0.23-67 months). A total of 17 patients developed brain metastases. Median survival time after diagnosis of brain metastases was 3.58 months (95% confidence interval (CI) 2.17, not available). A total of 30 patients developed metastases without any evidence of brain metastases until the time of death or last follow-up. Competing risk analysis identified three genes that were downregulated differentially in the patients with brain metastases versus non-brain metastatic disease: CD37 (0.017), cystatin A (0.022), and IL-23A (0.027). Other factors associated with brain metastases include: stage T ( P ⩽ 8.3e-6) and stage N ( P= 6.8e-4).

Conclusions

We have identified three genes, CD37, cystatin A, and IL-23A, for which downregulation of gene expression was associated with a greater propensity for developing brain metastases. Validation of these biomarkers could have implications on surveillance patterns in patients with brain metastases from NSCLC."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.org/dc/terms/identifier"doi:10.1177/1724600818803104"xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Su J."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Watabe K."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Taylor J.M."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Ruiz J."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"O'Neill S."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Xing F."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Pasche B."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Miller L.D."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Chan M.D."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Lo H.W."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Petty W.J."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Dotson T."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Metheny-Barlow L.J."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Bellinger C."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"Dohm A."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/author"McTyre E.R."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/name"Int J Biol Markers"xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/pages"90-97"xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/title"Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial."xsd:string
http://purl.uniprot.org/citations/30854931http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/30854931http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30854931
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