| http://purl.uniprot.org/citations/30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30864948 | http://www.w3.org/2000/01/rdf-schema#comment | "PSD-95 MAGUK family scaffold proteins are multi-domain organisers of synaptic transmission that contain three PDZ domains followed by an SH3-GK domain tandem. This domain architecture allows coordinated assembly of protein complexes composed of neurotransmitter receptors, synaptic adhesion molecules and downstream signalling effectors. Here we show that binding of monomeric CRIPT-derived PDZ3 ligands to the third PDZ domain of PSD-95 induces functional changes in the intramolecular SH3-GK domain assembly that influence subsequent homotypic and heterotypic complex formation. We identify PSD-95 interactors that differentially bind to the SH3-GK domain tandem depending on its conformational state. Among these interactors, we further establish the heterotrimeric G protein subunit Gnb5 as a PSD-95 complex partner at dendritic spines of rat hippocampal neurons. The PSD-95 GK domain binds to Gnb5, and this interaction is triggered by CRIPT-derived PDZ3 ligands binding to the third PDZ domain of PSD-95, unraveling a hierarchical binding mechanism of PSD-95 complex formation."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41299"xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Freund C."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Rademacher N."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Shoichet S.A."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Kunde S.A."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/author | "Kuropka B."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/pages | "e41299"xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/title | "Intramolecular domain dynamics regulate synaptic MAGUK protein interactions."xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30864948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30864948 |
| http://purl.uniprot.org/citations/30864948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30864948 |
| http://purl.uniprot.org/uniprot/#_A8K2R5-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_B7Z3U2-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_B7Z4H2-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_B3KWS4-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_O14775-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_B7Z647-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_B9EGL1-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_O14909-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |
| http://purl.uniprot.org/uniprot/#_P78352-mappedCitation-30864948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30864948 |