| http://purl.uniprot.org/citations/30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30867227 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of the skin epidermis requires tight spatiotemporal control over the activity of several signaling pathways; however, the mechanisms that orchestrate these events remain poorly understood. Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and growth. In utero RNAi-mediated silencing of Abi1 or Wasf2 induced cellular hyperproliferation and defects in architecture of the interfollicular epidermis (IFE) and delayed hair follicle growth. Unexpectedly, SOX9, a hair follicle growth regulator, was aberrantly expressed throughout the IFE of the mutant embryos, and its forced overexpression mimicked the Wave complex loss-of-function phenotype. Moreover, Wnt signaling, which regulates SOX9+ cell specification, was up-regulated in Wave complex loss-of-function IFE. Importantly, we show that the Wave complex regulates filamentous actin content and that a decrease in actin levels is sufficient to elevate Wnt/β-catenin signaling. Our results identify a novel role for Wave complex- and actin-regulated signaling via Wnt and SOX9 in skin development."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201807216"xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Cohen J."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Padmanabhan K."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Luxenburg C."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Raviv S."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Adir O."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/author | "Soffer A."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/pages | "1390-1406"xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/title | "The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling."xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://purl.uniprot.org/core/volume | "218"xsd:string |
| http://purl.uniprot.org/citations/30867227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30867227 |
| http://purl.uniprot.org/citations/30867227 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30867227 |
| http://purl.uniprot.org/uniprot/#_B1AUN0-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_B7ZCU0-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_B7ZCU2-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_B7ZCU3-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_B7ZCU4-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_B7ZCU5-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_J3QNK8-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_Q8BH43-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |
| http://purl.uniprot.org/uniprot/#_Q8BZD7-mappedCitation-30867227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30867227 |