| http://purl.uniprot.org/citations/30868916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30868916 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-sensitive potassium channels (KATP) may mediate a potential neuroprotective role in Alzheimer's disease (AD). Given that exposure to Aβ1-42 in cultured primary cholinergic neurons for 72 h significantly upregulates the expression of KATP subunits Kir6.2/SUR1, we aim to study the underlying signal transduction mechanisms that are involved in Aβ1-42-induced upregulation of KATP subunits Kir6.2/SUR1. In the present study, we first identified the primary cultured rat cortical and hippocampal neurons using immunocytochemistry. 0.5 μM NF-κB inhibitor SN-50, 2 μM p38MAPK inhibitor SB203580 or 2 μM PKC inhibitor Chelerythrine chloride (CTC) were then added in three separate groups, followed by 2 μM Aβ1-42 30 min later in all 3 groups. Western Blot was performed 72 h later to detect the expression of KATP subunits Kir6.2/SUR1. We found that Aβ1-42 significantly increased the level of KATP subunits Kir6.2/SUR1 expression at 72 h when compared with the control group ( p < 0.05). However, when compared with the Aβ1-42 group, the level of KATP subunits Kir6.2/SUR1 expression at 72 h significantly decreased in the SN50 + Aβ1-42 group, SB203580 + Aβ1-42 group, and the CTC + Aβ1-42 group ( p < 0.05). Our findings suggest that the NF-κB, p38 MAPK, and PKC signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Aβ1-42 cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of AD."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.org/dc/terms/identifier | "doi:10.1177/0960327119833742"xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Ma G."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Tan S."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Xia C."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Ng K.P."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/author | "Ba M."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/name | "Hum Exp Toxicol"xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/pages | "665-674"xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/title | "Abeta1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-kappaB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons."xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/30868916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30868916 |
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