| http://purl.uniprot.org/citations/30872080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30872080 | http://www.w3.org/2000/01/rdf-schema#comment | "TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which inactivates the enzyme and has been found in human patients with lupus-like disorders. The Trex1D18N/D18N mice exhibited systemic inflammation that consistently recapitulates many characteristics of human AGS and SLE. Importantly, ablation of cGas gene in the Trex1D18N/D18N mice rescued the lethality and all detectable pathological phenotypes, including multi-organ inflammation, interferon stimulated gene induction, autoantibody production and aberrant T-cell activation. These results indicate that cGAS is a key mediator in the autoimmune disease associated with defective TREX1 function, providing additional insights into disease pathogenesis and guidance to the development of therapeutics for human systemic autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jaut.2019.03.001"xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Du H."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Ye W."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/author | "Xiao N."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/name | "J Autoimmun"xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/pages | "84-94"xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/title | "cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model."xsd:string |
| http://purl.uniprot.org/citations/30872080 | http://purl.uniprot.org/core/volume | "100"xsd:string |
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