| http://purl.uniprot.org/citations/30872678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30872678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30872678 | http://www.w3.org/2000/01/rdf-schema#comment | "The strongest genetic risk factor of Behçet's disease (BD) is HLA-B*51. Our group previously reported that HLA-A*26 is independently associated with the risk of the onset of BD apart from HLA-B*51. Here, we re-evaluated the association between HLA-A*26 and BD in the Japanese population. We also performed a comprehensive literature search and meta-analyzed the extracted published data concerning the relationship between HLA-A*26 and BD to estimate the odds ratio (OR) of HLA-A*26 to BD. In this study, we genotyped 611 Japanese BD patients and 2,955 unrelated ethnically matched healthy controls. Genotyping results showed that the phenotype frequency of HLA-A*26 was higher in BD patients than in controls (OR = 2.12, 95% CI: 1.75-2.56). Furthermore, within the HLA-B*51-negative populations, the phenotype frequency of HLA-A*26 was significantly higher in BD patients than in controls (OR = 3.10, 95% CI: 2.43-3.95). Results obtained from meta-analysis combined with our data showed that the modified OR of HLA-A*26 became 1.80 (95% CI:1.58-2.06), whereas within the HLA-B*51-negative population, the modified OR became 4.02 (95% CI: 2.29-7.05). A subgroup analysis arranged by the geographical regions showed HLA-A*26 is in fact associated with the onset of BD in Northeast Asia (OR = 2.11, 95% CI: 1.75-2.56), but not in the Middle East or in Europe."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-40824-y"xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-40824-y"xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Yamane T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Yamane T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Nakamura J."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Nakamura J."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Ota M."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Ota M."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mizuki N."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mizuki N."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Meguro A."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Meguro A."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mihara T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mihara T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Ishii G."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Ishii G."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Kawagoe T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Kawagoe T."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mizuki Y."xsd:string |
| http://purl.uniprot.org/citations/30872678 | http://purl.uniprot.org/core/author | "Mizuki Y."xsd:string |