| http://purl.uniprot.org/citations/30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30880028 | http://www.w3.org/2000/01/rdf-schema#comment | "MMP-12 is a metalloproteinase (MMP) mainly secreted by macrophages and regulating the degradation of the extracellular matrix. MMP-12 is related to several diseases such as emphysema, myocardial infarction and liver fibrosis. However, the functions associated with inflammation of MMP-12 in macrophages have not yet been fully investigated. Therefore, the aim of this study is to elucidate the role of MMP-12 in mouse macrophages during inflammation. Here we show by flow cytometry that MMP-12 was closely associated with the number of F4/80 + macrophages from mouse liver following exposure to LPS. Pro-inflammatory cytokines as well as the proliferation of RAW 264.7 cell line was modulated by MMP-12 knock down as illustrated by qRT-PCR, flow cytometry, CCK-8, Western Blot and EdU staining assays. Furthermore, down-regulation of MMP-12 decreased the expression and the phosphorylation levels of P38 and ERK1/2. Taken together, these data show that MMP-12 contributes to the proliferation of mouse macrophages as well as the secretion of IL-1β, IL-6, TNF-α, CXCL1 and CXCL3 through the ERK/P38 MAPK signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2019.03.018"xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Liao G."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Guan C."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/pages | "182-190"xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/title | "MMP-12 regulates proliferation of mouse macrophages via the ERK/P38 MAPK pathways during inflammation."xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://purl.uniprot.org/core/volume | "378"xsd:string |
| http://purl.uniprot.org/citations/30880028 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30880028 |
| http://purl.uniprot.org/citations/30880028 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30880028 |
| http://purl.uniprot.org/uniprot/#_D3Z705-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/#_D6RJI9-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/#_P34960-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/#_Q3TCW6-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/#_Q6GX99-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/#_Q8BJC0-mappedCitation-30880028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/Q6GX99 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/P34960 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30880028 |
| http://purl.uniprot.org/uniprot/Q3TCW6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30880028 |