| http://purl.uniprot.org/citations/30890370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30890370 | http://www.w3.org/2000/01/rdf-schema#comment | "Transmembrane prostate androgen-induced protein (TMEPAI) is a type I transmembrane protein induced by several intracellular signaling pathways such as androgen, TGF-β, EGF, and Wnt signaling. It has been reported that TMEPAI functions to suppress TGF-β and androgen signaling but here, we report a novel function of TMEPAI in Wnt signaling suppression. First, we show that TMEPAI significantly inhibits TCF/LEF transcriptional activity stimulated by Wnt3A, LiCl, and β-catenin. Mechanistically, TMEPAI overexpression prevented β-catenin accumulation in the nucleus and TMEPAI knockout in triple negative breast cancer cell lines promoted β-catenin stability and nuclear accumulation together with increased mRNA levels of Wnt target genes AXIN2 and c-MYC. The presence of TGF-β type I receptor kinase inhibitor did not affect the enhanced mRNA expression of AXIN2 in TMEPAI knockout cells. These data suggest that TMEPAI suppresses Wnt signaling by interfering with β-catenin stability and nuclear translocation in a TGF-β signaling-independent manner."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2019.03.016"xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Hwang J."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Anwar F."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Abdelaziz M."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Amalia R."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/author | "Puteri M.U."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/pages | "24-33"xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/title | "TMEPAI/PMEPA1 inhibits Wnt signaling by regulating beta-catenin stability and nuclear accumulation in triple negative breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/30890370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30890370 |
| http://purl.uniprot.org/citations/30890370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30890370 |
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| http://purl.uniprot.org/uniprot/#_Q66K30-mappedCitation-30890370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30890370 |
| http://purl.uniprot.org/uniprot/#_Q969W9-mappedCitation-30890370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30890370 |
| http://purl.uniprot.org/uniprot/Q5JY37 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30890370 |
| http://purl.uniprot.org/uniprot/Q969W9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30890370 |
| http://purl.uniprot.org/uniprot/Q66K30 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30890370 |