| http://purl.uniprot.org/citations/30894377 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30894377 | http://www.w3.org/2000/01/rdf-schema#comment | "CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8+ T cell-dependent manner. DNAM-1/CD226, Batf3, IL12p35, and IFNγ were also critical, and CD96-deficient CD8+ T cells promoted greater tumor control than CD96-sufficient CD8+ T cells. The antitumor activity of anti-CD96 therapy was independent of Fc-mediated effector function and was more effective in dual combination with blockade of a number of immune checkpoints, including PD-1, PD-L1, TIGIT, and CTLA-4. We consistently observed coexpression of PD-1 with CD96 on CD8+ T lymphocytes in tumor-infiltrating leukocytes both in mouse and human cancers using mRNA analysis, flow cytometry, and multiplex IHF. The combination of anti-CD96 with anti-PD-1 increased the percentage of IFNγ-expressing CD8+ T lymphocytes. Addition of anti-CD96 to anti-PD-1 and anti-TIGIT resulted in superior antitumor responses, regardless of the ability of the anti-TIGIT isotype to engage FcR. The optimal triple combination was also dependent upon CD8+ T cells and IFNγ. Overall, these data demonstrate that CD96 is an immune checkpoint on CD8+ T cells and that blocking CD96 in combination with other immune-checkpoint inhibitors is a strategy to enhance T-cell activity and suppress tumor growth."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.org/dc/terms/identifier | "doi:10.1158/2326-6066.cir-18-0637"xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Lan R."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Mittal D."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Madore J."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Aguilera A.R."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Dougall W.C."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Teng M.W.L."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Long G.V."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Johnston R.J."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Korman A."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Scolyer R.A."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Lepletier A."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Stannard K."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Bettington M.L."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Blake S.J."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Whitehall V.L.J."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/author | "Siemers N."xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/name | "Cancer Immunol Res"xsd:string |
| http://purl.uniprot.org/citations/30894377 | http://purl.uniprot.org/core/pages | "559-571"xsd:string |