| http://purl.uniprot.org/citations/30902577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30902577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30902577 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishing the balance between positive and negative innate immune mechanisms is crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two previously unlinked innate immune receptor families: RIG-I, an anti-viral cytosolic receptor activated type I interferon production, and NLR (nucleotide-binding domain, leucine repeat domain-containing protein). We show that NLRP12 dampens RIG-I-mediated immune signaling against RNA viruses by controlling RIG-I's association with its adaptor MAVS. The nucleotide-binding domain of NLRP12 interacts with the ubiquitin ligase TRIM25 to prevent TRIM25-mediated, Lys63-linked ubiquitination and activation of RIG-I. NLRP12 also enhances RNF125-mediated, Lys48-linked degradative ubiquitination of RIG-I. Vesicular stomatitis virus (VSV) infection downregulates NLRP12 expression to allow RIG-I activation. Myeloid-cell-specific Nlrp12-deficient mice display a heightened interferon and TNF response and are more resistant to VSV infection. These results indicate that NLRP12 functions as a checkpoint for anti-viral RIG-I activation."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2019.02.013"xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2019.02.013"xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Brickey W.J."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Brickey W.J."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen S.T."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen S.T."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen S.Y."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Chen S.Y."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Kang H.R."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Kang H.R."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Song M.J."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Song M.J."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Dzhagalov I."xsd:string |
| http://purl.uniprot.org/citations/30902577 | http://purl.uniprot.org/core/author | "Dzhagalov I."xsd:string |