| http://purl.uniprot.org/citations/30905148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30905148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30905148 | http://www.w3.org/2000/01/rdf-schema#comment | "The pericyclases are a growing superfamily of enzymes that catalyze pericyclic reactions. We report a pericyclase IccD catalyzing an inverse-electron demand Diels-Alder (IEDDA) reaction with a rate acceleration of 3 × 105-fold in the biosynthesis of fungal natural product ilicicolin H. We demonstrate IccD is highly periselective toward the IEDDA cycloaddition over a competing normal electron demand Diels-Alder (NEDDA) reaction from an ambimodal transition state. A predicted flavoenzyme IccE was identified to epimerize the IEDDA product 8-epi-ilicicolin H to ilicicolin H, a step that is critical for the observed antifungal activity of ilicicolin H. Our results reveal the ilicicolin H biosynthetic pathway and add to the collection of pericyclic reactions that are catalyzed by pericyclases."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.org/dc/terms/identifier | "doi:10.1021/jacs.9b02204"xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.org/dc/terms/identifier | "doi:10.1021/jacs.9b02204"xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Zhao Y.L."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Zhao Y.L."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Houk K.N."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Houk K.N."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Ohashi M."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Ohashi M."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Jamieson C.S."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/author | "Jamieson C.S."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/name | "J. Am. Chem. Soc."xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/pages | "5659-5663"xsd:string |
| http://purl.uniprot.org/citations/30905148 | http://purl.uniprot.org/core/pages | "5659-5663"xsd:string |