| http://purl.uniprot.org/citations/30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30905672 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab35, a master regulator of membrane trafficking, regulates diverse cellular processes and is associated with various human diseases. Although a number of effectors have been identified, the molecular basis of Rab35-effector interactions remains unclear. Here, we provide the high-resolution crystal structures of Rab35 in complex with its two specific effectors ACAP2 and RUSC2, respectively. In the Rab35/ACAP2 complex structure, Rab35 binds to the terminal ankyrin repeat and a C-terminal extended α helix of ACAP2, revealing a previously uncharacterized binding mode both for Rabs and ankyrin repeats. In the Rab35/RUSC2 complex structure, Arg1015 of RUSC2 functions as a "pseudo-arginine finger" that stabilizes the GTP-bound Rab35, thus facilitating the assembly of Rab35/RUSC2 complex. The structural analysis allows us to design specific Rab35 mutants capable of eliminating Rab35/ACAP2 and Rab35/RUSC2 interactions, but not interfering with other effector bindings. The atomic structures also offer possible explanations to disease-associated mutants identified at the Rab35-effector interfaces."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2019.02.008"xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/pages | "729-740.e3"xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/title | "Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase."xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/30905672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30905672 |
| http://purl.uniprot.org/citations/30905672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30905672 |
| http://purl.uniprot.org/uniprot/#_Q15057-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/#_B4DSL8-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/#_B4DTA6-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/#_B4DPL4-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/#_Q15286-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/#_Q8N2Y8-mappedCitation-30905672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/Q15057 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/Q8N2Y8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30905672 |
| http://purl.uniprot.org/uniprot/B4DPL4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/30905672 |