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| http://purl.uniprot.org/citations/30908912 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinases are among the most important families of enzymes involved in cell signaling. In this study, we employed a recently developed parallel-reaction monitoring (PRM)-based targeted proteomic method to examine the reprogramming of the human kinome during colorectal cancer (CRC) metastasis. We were able to quantify the relative expression of 299 kinase proteins in a pair of matched primary/metastatic CRC cell lines. We also found that, among the differentially expressed kinases, phosphoribosyl pyrophosphate synthetase 2 (PRPS2) promotes the migration and invasion of cultured CRC cells through regulating the activity of matrix metalloproteinase 9 (MMP-9) and the expression of E-cadherin. Moreover, we found that the up-regulation of PRPS2 in metastatic CRC cells could be induced by the MYC proto-oncogene. Together, our unbiased kinome profiling approach led to the identification, for the first time, of PRPS2 as a promoter for CRC metastasis."xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jproteome.9b00119"xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/author | "Miao W."xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/pages | "2279-2286"xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/title | "Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis."xsd:string |
| http://purl.uniprot.org/citations/30908912 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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