| http://purl.uniprot.org/citations/30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30912293 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell receptors possess the unique ability to survey and respond to their permanently modified ligands, self HLA-I molecules bound to non-self peptides of various origin. This highly specific immune function is impaired following hematopoietic stem cell transplantation (HSCT) for a timespan of several months needed for the maturation of T-cells. Especially, the progression of HCMV disease in immunocompromised patients induces life-threatening situations. Therefore, the need for a new immune system that delivers vital and potent CD8+ T-cells carrying TCRs that recognize even one human cytomegalovirus (HCMV) peptide/HLA molecule and clear the viral infection long term becomes obvious. The transcription and translation of HCMV proteins in the lytic cycle is a precisely regulated cascade of processes, therefore, it is a highly sensitive challenge to adjust the exact time point of HCMV-peptide recruitment over self-peptides. We utilized soluble HLA technology in HCMV-infected fibroblasts and sequenced naturally sHLA-A*24:02 presented HCMV-derived peptides. One peptide of 14 AAs length derived from the IE2 antigen induced the strongest T-cell responses; this peptide can be detected with a low ranking score in general peptide prediction databanks. These results highlight the need for elaborate and HLA-allele specific peptide selection."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.13537"xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Blasczyk R."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Huyton T."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Schulz R."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Bade-Doeding C."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Martens J."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Ho G.T."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Kunze-Schumacher H."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/author | "Pump W.C."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/name | "HLA"xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/pages | "25-38"xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/title | "Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity."xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/30912293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30912293 |
| http://purl.uniprot.org/citations/30912293 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |
| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-30912293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30912293 |