| http://purl.uniprot.org/citations/30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30914799 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycoprotein Nmb (GPNMB) is overexpressed in triple-negative and basal-like breast cancers and its expression is predictive of poor prognosis within this aggressive breast cancer subtype. GPNMB promotes breast cancer growth, invasion, and metastasis; however, its role in mammary tumor initiation remains unknown. To address this question, we overexpressed GPNMB in the mammary epithelium to generate MMTV/GPNMB transgenic mice and crossed these animals to the MMTV/Wnt-1 mouse model, which is known to recapitulate features of human basal breast cancers. We show that GPNMB alone does not display oncogenic properties; however, its expression dramatically accelerates tumor onset in MMTV/Wnt-1 mice. MMTV/Wnt-1 × MMTV/GPNMB bigenic mice also exhibit a significant increase in the growth rate of established primary tumors, which is attributable to increased proliferation and decreased apoptosis. To elucidate molecular mechanisms underpinning the tumor-promoting effects of GPNMB in this context, we interrogated activated pathways in tumors derived from the MMTV/Wnt-1 and MMTV/Wnt-1 × MMTV/GPNMB mice using RPPA analysis. These data revealed that MMTV/Wnt-1 × MMTV/GPNMB bigenic tumors exhibit a pro-growth signature characterized by elevated PI3K/AKT/mTOR signaling and increased β-catenin activity. Furthermore, we extended these observations to an independent Wnt-1 expressing model of aggressive breast cancer, and confirmed that GPNMB enhances canonical Wnt pathway activation, as evidenced by increased β-catenin transcriptional activity, in breast cancer cells and tumors co-expressing Wnt-1 and GPNMB. GPNMB-dependent engagement of β-catenin occurred, in part, through AKT activation. Taken together, these data ascribe a novel, pro-growth role for GPNMB in Wnt-1 expressing basal breast cancers."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-019-0793-7"xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Russo C."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Mills G.B."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Perkins D."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Siegel P.M."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Siwak D.R."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Annis M.G."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "MacDonald P.A."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/author | "Maric G."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/pages | "5294-5307"xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/title | "GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and beta-catenin activity."xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/30914799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30914799 |
| http://purl.uniprot.org/citations/30914799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30914799 |
| http://purl.uniprot.org/uniprot/#_B2R5R1-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_B4DKZ5-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_B4DN79-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_B4E3D4-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_B4DZS5-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_A8K7R3-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |
| http://purl.uniprot.org/uniprot/#_B4DLJ7-mappedCitation-30914799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30914799 |