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http://purl.uniprot.org/citations/30917315http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30917315http://www.w3.org/2000/01/rdf-schema#comment"The Foxp3 transcription factor is a crucial determinant of both regulatory T (TREG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 transcriptional output, and this involves both transcriptional and post-translational regulation. Here, we show that during T cell activation, phosphorylation of Foxp3 in TREG cells can be regulated by a TGF-β activated kinase 1 (TAK1)-Nemo-like kinase (NLK) signaling pathway. NLK interacts and phosphorylates Foxp3 in TREG cells, resulting in the stabilization of protein levels by preventing association with the STUB1 E3-ubiquitin protein ligase. Conditional TREG cell NLK-knockout (NLKΔTREG) results in decreased TREG cell-mediated immunosuppression in vivo, and NLK-deficient TREG cell animals develop more severe experimental autoimmune encephalomyelitis. Our data suggest a molecular mechanism, in which stimulation of TCR-mediated signaling can induce a TAK1-NLK pathway to sustain Foxp3 transcriptional activity through the stabilization of protein levels, thereby maintaining TREG cell suppressive function."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.org/dc/terms/identifier"doi:10.1016/j.celrep.2019.02.087"xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Wu X."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Wei P."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Coffer P.J."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Pan F."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Rudensky A."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Pals C.E.G.M."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Fleskens V."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Zaiss D.M."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Hemmers S."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Groenewold V."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Vos H.J."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"Minutti C.M."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/author"McCrae J."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/name"Cell Rep"xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/pages"3600-3612.e6"xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/title"Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells."xsd:string
http://purl.uniprot.org/citations/30917315http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/30917315http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30917315
http://purl.uniprot.org/citations/30917315http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/30917315
http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-30917315http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30917315
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