| http://purl.uniprot.org/citations/30923192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30923192 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammalian skin, ninein localizes to the centrosomes of progenitor cells and relocates to the cell cortex upon differentiation of keratinocytes, where cortical arrays of microtubules are formed. To examine the function of ninein in skin development, we use epidermis-specific and constitutive ninein-knockout mice to demonstrate that ninein is necessary for maintaining regular protein levels of the differentiation markers filaggrin and involucrin, for the formation of desmosomes, for the secretion of lamellar bodies, and for the formation of the epidermal barrier. Ninein-deficient mice are viable but develop a thinner skin with partly impaired epidermal barrier. We propose two underlying mechanisms: first, ninein contributes to spindle orientation during the division of progenitor cells, whereas its absence leads to misoriented cell divisions, altering the pool of progenitor cells. Second, ninein is required for the cortical organization of microtubules in differentiating keratinocytes, and for the cortical re-localization of microtubule-organizing proteins, and may thus affect any mechanisms that depend on localized microtubule-dependent transport."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201900373"xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/author | "Hsu C.Y."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/author | "Merdes A."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/author | "Bierkamp C."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/author | "Chemin C."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/author | "Lecland N."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/pages | "e201900373"xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/title | "Epidermal development requires ninein for spindle orientation and cortical microtubule organization."xsd:string |
| http://purl.uniprot.org/citations/30923192 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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