| http://purl.uniprot.org/citations/30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30926782 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in the course of backcrossing to the FVB/N background. Microsatellite analyses indicate that this cancer phenotype is linked to a 20 Mb region of 129P2 chromosome 15 harboring the Wnt7b gene, which is preferentially expressed from the 129P2 allele in skin carcinomas and derived cell lines. ChIPseq analysis shows enrichment of H3K27-Ac, a mark for active enhancers, in the 5' region of the Wnt7b 129P2 gene. The Wnt7b 129P2 allele appears sufficient to cause in vitro transformation of Cdkn2ab-deficient cell lines primarily through CDK6 activation. These results point to a critical role of the Cdkn2ab locus in keeping the oncogenic potential of physiological levels of WNT signaling in check and illustrate that GWAS-based searches for cancer predisposing allelic variants can be enhanced by including defined somatically acquired lesions as an additional input."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-09321-8"xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Bhaskaran R."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Song J.Y."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Krimpenfort P."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "de Wit E."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Teunissen H."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Snoek M."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "Lambooij J.P."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/author | "van der Weide R."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/pages | "1425"xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/title | "A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30926782 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30926782 |
| http://purl.uniprot.org/citations/30926782 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30926782 |
| http://purl.uniprot.org/uniprot/#_A7LP29-mappedCitation-30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30926782 |
| http://purl.uniprot.org/uniprot/#_O54846-mappedCitation-30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30926782 |
| http://purl.uniprot.org/uniprot/#_Q3UNM8-mappedCitation-30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30926782 |
| http://purl.uniprot.org/uniprot/#_P51480-mappedCitation-30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30926782 |
| http://purl.uniprot.org/uniprot/#_P55271-mappedCitation-30926782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30926782 |