| http://purl.uniprot.org/citations/30936870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30936870 | http://www.w3.org/2000/01/rdf-schema#comment | "The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Common lymphoid precursors (CLPs) and a near complete block in B-cell development. In the thymus, Early T-cell progenitors (ETPs) were reduced and T-cell development perturbed, resulting in reduced CD4 T- and increased γδ T-cell numbers. In contrast, hematopoietic stem cells (HSCs), erythro-myeloid progenitors, and innate immune cells were unaffected showing that E2-2 and HEB are dispensable for the ancestral hematopoietic lineages. Taken together, this E-protein dependence suggests that the appearance of the full Gnathostomata E-protein repertoire was critical to reinforce the gene regulatory circuits that drove the emergence and expansion of the lineages constituting humoral immunity."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2019.00455"xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "De Paepe A."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Gustafsson C."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Schachtrup C."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Bouderlique T."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Schachtrup K."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Holmberg D."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Hils M."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Krstic A."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Mansson R."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Kharazi S."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/author | "Pena-Perez L."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/pages | "455"xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/title | "The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification."xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30936870 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30936870 |
| http://purl.uniprot.org/citations/30936870 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30936870 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTR9-mappedCitation-30936870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30936870 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTU7-mappedCitation-30936870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30936870 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTW1-mappedCitation-30936870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30936870 |