| http://purl.uniprot.org/citations/30939162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30939162 | http://www.w3.org/2000/01/rdf-schema#comment | "Cervical cancer is the second most deadly gynecological tumor worldwide. MicroRNAs (miRNAs) play very important roles in tumor oncogenesis and progression. The mechanism of post-transcription regulation of WTX gene is still unknown. A series of differential miRNAs were discovered by microarray analysis comparing three pairs of primary cervical cancer specimens and their relapsed tumors from three patients. Quantitative reverse transcriptase PCR (qRT-PCR), Western Blot (WB) and Immunohistochemistry (IHC) was used to detect the expression of miR-4524b-5p and WTX in cervical cell lines and tissues. The biological function of miR-4524b-5p and WTX was investigated through knockdown and overexpression with inhibitor/siRNA and mimic/plasmid in vitro and in vivo. In this study, we found that miR-4524b-5p is highly expressed in relapsed cervical cancer specimens. Combined in vitro and in vivo experiments, showed that miR-4524b-5p could regulate the migration and invasion ability of cervical cancer. Furthermore, we also found that miR-4524b-5p could regulate the migration and invasion of cervical cancer by targeting WTX and that WTX could regulate the expression of β-catenin. Taken together, our data identified a miR-4524b-5p/WTX/β-catenin regulatory axis for cervical cancer, and miR-4524b-5p may be a potential target for cervical cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0214822"xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Gan Y."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Yin G."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Xiao Q."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Wu A."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Ouyang C."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/author | "Shu G."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/pages | "e0214822"xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/title | "MiR-4524b-5p/WTX/beta-catenin axis functions as a regulator of metastasis in cervical cancer."xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/30939162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30939162 |
| http://purl.uniprot.org/citations/30939162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30939162 |