| http://purl.uniprot.org/citations/30944247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30944247 | http://www.w3.org/2000/01/rdf-schema#comment | "Antibody-mediated lymphoablation is used in solid organ and stem cell transplantation and autoimmunity. Using murine anti-thymocyte globulin (mATG) in a mouse model of heart transplantation, we previously reported that the homeostatic recovery of CD8+ T cells requires help from depletion-resistant memory CD4+ T cells delivered through CD40-expressing B cells. This study investigated the mechanisms by which B cells mediate CD8+ T cell proliferation in lymphopenic hosts. While CD8+ T cell recovery required MHC class I expression in the host, the reconstitution occurred independently of MHC class I, MHC class II, or CD80/CD86 expression on B cells. mATG lymphoablation upregulated the B cell expression of several cytokine genes, including IL-15 and IL-27, in a CD4-dependent manner. Neither treatment with anti-CD122 mAb nor the use of IL-15Rα-/-recipients altered CD8+ T cell recovery after mATG treatment, indicating that IL-15 may be dispensable for T cell proliferation in our model. Instead, IL-27 neutralization or the use of IL-27Rα-/-CD8+ T cells inhibited CD8+ T cell proliferation and altered the phenotype and cytokine profile of reconstituted CD8+ T cells. Our findings uncover what we believe is a novel role of IL-27 in lymphopenia-induced CD8+ T cell proliferation and suggest that targeting B cell-derived cytokines may increase the efficacy of lymphoablation and improve transplant outcomes."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.125489"xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Fan R."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Min B."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Nicosia M."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Fairchild R.L."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Valujskikh A."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Gorbacheva V."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Ayasoufi K."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Hasgur S."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Keslar K.S."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/author | "Zwick D.B."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/pages | "125489"xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/title | "Interleukin-27 promotes CD8+ T cell reconstitution following antibody-mediated lymphoablation."xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/30944247 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30944247 |
| http://purl.uniprot.org/citations/30944247 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30944247 |
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| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-30944247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944247 |
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| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-30944247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944247 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-30944247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944247 |