| http://purl.uniprot.org/citations/30944319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30944319 | http://www.w3.org/2000/01/rdf-schema#comment | "Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2+-dependent inactivation; no such inactivation is observed in the cardiac Na+ channel (NaV1.5). Taken together, the crystal structures of the NaV1.4 C-terminal domain relevant complexes and thermodynamic binding data presented here provide a rationale for this isoform difference. A Ca2+-dependent CaM N-lobe binding site previously identified in NaV1.5 is not present in NaV1.4 allowing the N-lobe to signal other regions of the NaV1.4 channel. Consistent with this mechanism, removing this binding site in NaV1.5 unveils robust Ca2+-dependent inactivation in the previously insensitive isoform. These findings suggest that Ca2+-dependent inactivation is effected by CaM's N-lobe binding outside the NaV C-terminal while CaM's C-lobe remains bound to the NaV C-terminal. As the N-lobe binding motif of NaV1.5 is a mutational hotspot for inherited arrhythmias, the contributions of mutation-induced changes in CDI to arrhythmia generation is an intriguing possibility."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-09570-7"xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Amzel L.M."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Gabelli S.B."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Ben-Johny M."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Tomaselli G.F."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Srinivasan L."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Farinelli F."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Yoder J.B."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/author | "Shoemaker S.R."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/pages | "1514"xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/title | "Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif."xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30944319 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30944319 |
| http://purl.uniprot.org/citations/30944319 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30944319 |
| http://purl.uniprot.org/uniprot/#_D3YHE8-mappedCitation-30944319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944319 |
| http://purl.uniprot.org/uniprot/#_E9PHB6-mappedCitation-30944319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944319 |
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| http://purl.uniprot.org/uniprot/#_A3EY21-mappedCitation-30944319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944319 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M6R3-mappedCitation-30944319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30944319 |