| http://purl.uniprot.org/citations/30946007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30946007 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity. Mutation of the depalmitoylating enzyme palmitoyl-protein thioesterase 1 (PPT1) causes infantile neuronal ceroid lipofuscinosis (CLN1), a pediatric neurodegenerative disease. However, the role of protein depalmitoylation in synaptic maturation is unknown. Therefore, we studied synapse development in Ppt1-/- mouse visual cortex. We demonstrate that the developmental N-methyl-D-aspartate receptor (NMDAR) subunit switch from GluN2B to GluN2A is stagnated in Ppt1-/- mice. Correspondingly, Ppt1-/- neurons exhibit immature evoked NMDAR currents and dendritic spine morphology in vivo. Further, dissociated Ppt1-/- cultured neurons show extrasynaptic, diffuse calcium influxes and enhanced vulnerability to NMDA-induced excitotoxicity, reflecting the predominance of GluN2B-containing receptors. Remarkably, Ppt1-/- neurons demonstrate hyperpalmitoylation of GluN2B as well as Fyn kinase, which regulates surface retention of GluN2B. Thus, PPT1 plays a critical role in postsynapse maturation by facilitating the GluN2 subunit switch and proteostasis of palmitoylated proteins."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.40316"xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Srinivas R."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Yoshii A."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Berton F."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Francesconi W."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Koster K.P."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/author | "Alahmadi S."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/pages | "e40316"xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/title | "Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model."xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/30946007 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30946007 |
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