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http://purl.uniprot.org/citations/30950353http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/30950353http://www.w3.org/2000/01/rdf-schema#comment"

Background

SOX15 is a crucial transcription factor involved in the regulation of embryonic development and in the cell fate determination. It is also an important mediator of tumorigenesis in cancer.

Methods

Here, we sought to explore the expression patterns and biological functions of SOX15 in esophageal squamous cell carcinomas (ESCC). SOX15 was found aberrantly overexpressed in ESCC tumors.

Results

Experimentally, inhibition of SOX15 through RNAi suppressed cell proliferation in ESCC cells and sensitized cancer cells to paclitaxel, but not to Cisplatin. Moreover, inhibition of SOX15 significantly repressed the expression of genes associated with WNT and NOTCH signaling pathways, which may contribute to the increased sensitivity to paclitaxel.

Conclusion

In conclusion, the current study revealed that inhibition of SOX15 in ESCC cells sensitizes the ESCC cells to paclitaxel, suggesting that the SOX15 expression level may predict the therapeutic outcomes for paclitaxel treatment for ESCC."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.org/dc/terms/identifier"doi:10.2174/1566524019666190405121139"xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Chen X."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Guo X."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Li Z."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Wu H."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Yu J."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Xu Y."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Yu X."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Zhang M."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Gao T."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/author"Zhuang R."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/name"Curr Mol Med"xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/pages"349-356"xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/title"Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel."xsd:string
http://purl.uniprot.org/citations/30950353http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/30950353http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/30950353
http://purl.uniprot.org/citations/30950353http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/30950353
http://purl.uniprot.org/uniprot/#_O60248-mappedCitation-30950353http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30950353
http://purl.uniprot.org/uniprot/#_O95130-mappedCitation-30950353http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30950353
http://purl.uniprot.org/uniprot/#_O95131-mappedCitation-30950353http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/30950353
http://purl.uniprot.org/uniprot/O60248http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/30950353
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