| http://purl.uniprot.org/citations/30952607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30952607 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8+ T cells are affected in HSAN-I patients remains unknown. Here, we report that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened human T cell responses. Antigen stimulation and inflammation induced SPTLC2 expression, and murine T-cell-specific ablation of Sptlc2 impaired antiviral-T-cell expansion and effector function. Sptlc2 deficiency reduced sphingolipid biosynthetic flux and led to prolonged activation of the mechanistic target of rapamycin complex 1 (mTORC1), endoplasmic reticulum (ER) stress, and CD8+ T cell death. Protective CD8+ T cell responses in HSAN-I patient PBMCs and Sptlc2-deficient mice were restored by supplementing with sphingolipids and pharmacologically inhibiting ER stress-induced cell death. Therefore, SPTLC2 underpins protective immunity by translating extracellular stimuli into intracellular anabolic signals and antagonizes ER stress to promote T cell metabolic fitness."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2019.03.005"xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Seeman P."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Schmitt M."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Muller L."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Hotz-Wagenblatt A."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Brugger B."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Cui G."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Ming Y."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Auer-Grumbach M."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Timmerman V."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Schlotter-Weigel B."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Madi A."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Sandhoff R."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Koeppel J."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Loscher W.N."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Samstag Y."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Bonello-Palot N."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Mohr K."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Reindl M."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Weiss F."xsd:string |
| http://purl.uniprot.org/citations/30952607 | http://purl.uniprot.org/core/author | "Wabnitz G."xsd:string |