| http://purl.uniprot.org/citations/30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30953364 | http://www.w3.org/2000/01/rdf-schema#comment | "Resistance to chemotherapy represents a major cause for treatment failure in multiple myeloma (MM). Herein, this study was conducted to explore the effect of SDF-1/CXCR4 and interleukin-6 (IL-6) in MM cell adhesion-mediated chemoresistance. Enzyme-linked immunosorbent assay was applied to detect expressions of SDF-1α and IL-6 in MM patients and healthy controls. RPMI-8226 cells and isolated bone marrow stromal cells (BMSCs) were stimulated using recombinant SDF-1α and IL-6. Effect of cocultured BMSCs and RPMI-8226 cells on chemosensitivity and apoptosis of RPMI-8226 cells was analyzed. Effect of doxorubicin on the adhesion rate of RPMl-8226 cells to BMSCs was analyzed by calcitonin test. Effect of SDF-1α-induced upregulation of IL-6 on chemotherapeutic resistance and apoptosis of RPMI-8226 cells in adhesion state was analyzed. Cell adhesion model was treated with recombinant protein SDF-1α and phosphoinositide 3-kinase (P13K) inhibitor Wortmarmin. The levels of P13K and protein kinase B (AKT) and its phosphorylation as well as the expression of IL-6 were analyzed. SDF-1α was positively correlated with IL-6. Recombinant human SDF-1α increased IL-6 expression and induced IL-6 secretion in a time- and dose-dependent manner in BMSCs, which was inhibited by IL-6 and SDF-1α neutralizing antibodies. Coculture of MM cells with BMSCs increased the drug resistance and inhibited the apoptosis on MM cells. SDF-1α-induced IL-6 upregulation mediates chemoresistance and apoptosis of RPMI-8226 cells in adhesion state. SDF-1α may up-regulate the expression of IL-6 by activating the P13K/AKT signaling pathway. SDF-1/CXCR4 may up-regulate the expression of IL-6 through the activation of the P13K/AKT signaling pathway, thereby affecting the chemoresistance mediated by adhesion in MM cells."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.28570"xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/author | "Cheng P."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/author | "Tang S.M."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/author | "Liang H.M."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/author | "Lv Y.Q."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/pages | "19702-19714"xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/title | "Blockade of SDF-1/CXCR4 reduces adhesion-mediated chemoresistance of multiple myeloma cells via interacting with interleukin-6."xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/30953364 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30953364 |
| http://purl.uniprot.org/citations/30953364 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30953364 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_B4DVM1-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_B4DNV3-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_B4DNQ5-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_B5MC21-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_H9C875-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |
| http://purl.uniprot.org/uniprot/#_P05231-mappedCitation-30953364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30953364 |