| http://purl.uniprot.org/citations/30958798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30958798 | http://www.w3.org/2000/01/rdf-schema#comment | "DCs undergo metabolic reprogramming from a predominantly oxidative phosphorylation (OXPHOS) to glycolysis to mount an immunogenic response. The mechanism underpinning the metabolic reprogramming remains elusive. We demonstrate that miRNA-142 (miR-142) is pivotal for this shift in metabolism, which regulates the tolerogenic and immunogenic responses of DCs. In the absence of miR-142, DCs fail to switch from OXPHOS and show reduced production of proinflammatory cytokines and the ability to activate T cells in vitro and in in vivo models of sepsis and alloimmunity. Mechanistic studies demonstrate that miR-142 regulates fatty acid (FA) oxidation, which causes the failure to switch to glycolysis. Loss- and gain-of-function experiments identified carnitine palmitoyltransferase -1a (CPT1a), a key regulator of the FA pathway, as a direct target of miR-142 that is pivotal for the metabolic switch. Thus, our findings show that miR-142 is central to the metabolic reprogramming that specifically favors glycolysis and immunogenic response by DCs."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci123839"xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Fujiwara H."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Taylor A."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Bridges S."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Reddy P."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Saunders T."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Oravecz-Wilson K."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "McEachin R."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Peltier D.C."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/author | "Zajac C."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/pages | "2029-2042"xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/title | "miR-142 controls metabolic reprogramming that regulates dendritic cell activation."xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/30958798 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30958798 |
| http://purl.uniprot.org/citations/30958798 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30958798 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-30958798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30958798 |
| http://purl.uniprot.org/uniprot/#_A0A0B6VTJ4-mappedCitation-30958798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30958798 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-30958798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30958798 |