| http://purl.uniprot.org/citations/30970222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30970222 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein A-I (apoA-I), the main protein constituent of HDLs, increases insulin synthesis and insulin secretion in pancreatic β cells. ApoA-I also accepts cholesterol that effluxes from cells expressing ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1). Mice with conditional deletion of ABCA1 and ABCG1 in β cells [β-double knockout (DKO) mice] have increased islet cholesterol levels and reduced glucose-stimulated insulin secretion (GSIS). The project asks whether metabolic pathways are dysregulated in β-DKO mouse islets and whether this can be corrected, and GSIS improved, by treatment with apoA-I. β-DKO mice were treated with apoA-I or PBS, and islets were isolated for determination of GSIS. Total RNA was extracted from β-DKO and control mouse islets for microarray analysis. Metabolic pathways were interrogated by functional enrichment analysis. ApoA-I treatment improved GSIS in β-DKO but not control mouse islets. Plasma lipid and lipoprotein levels and islet cholesterol levels were also unaffected by treatment with apoA-I. Cholesterol metabolism, glucose metabolism, and inflammation pathways were dysregulated in β-DKO mouse islets. This was not corrected by treatment with apoA-I. In summary, apoA-I treatment improves GSIS by a cholesterol-independent mechanism, but it does not correct metabolic dysregulation in β-DKO mouse islets.-Hou, L., Tang, S., Wu, B. J., Ong, K.-L., Westerterp, M., Barter, P. J., Cochran, B. J., Tabet, F., Rye, K.-A. Apolipoprotein A-I improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.201802512rr"xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Hou L."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Westerterp M."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Barter P.J."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Rye K.A."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Wu B.J."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Ong K.L."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Tabet F."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/author | "Cochran B.J."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/pages | "8479-8489"xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/title | "Apolipoprotein A-I improves pancreatic beta-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1."xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/30970222 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30970222 |
| http://purl.uniprot.org/citations/30970222 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30970222 |
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| http://purl.uniprot.org/uniprot/#_B7XCW9-mappedCitation-30970222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30970222 |
| http://purl.uniprot.org/uniprot/#_A0A494B9K1-mappedCitation-30970222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30970222 |
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| http://purl.uniprot.org/uniprot/#_A0A494BA50-mappedCitation-30970222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30970222 |