| http://purl.uniprot.org/citations/30976076 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30976076 | http://www.w3.org/2000/01/rdf-schema#comment | "Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we show that GSDME-N also permeabilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome. Cytochrome c release and caspase-3 activation in response to intrinsic and extrinsic apoptotic stimuli are significantly reduced in GSDME-deficient cells comparing with wild type cells. GSDME deficiency also accelerates cell growth in culture and in a mouse model of melanoma. Phosphomimetic mutation of the highly conserved phosphorylatable Thr6 residue of GSDME, inhibits its pore-forming activity, thus uncovering a potential mechanism by which GSDME might be regulated. Like GSDME-N, inflammasome-generated gasdermin D-N (GSDMD-N), can also permeabilize the mitochondria linking inflammasome activation to downstream activation of the apoptosome. Collectively, our results point to a role of gasdermin proteins in targeting the mitochondria to promote cytochrome c release to augment the mitochondrial apoptotic pathway."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-09397-2"xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Fernandes-Alnemri T."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Rogers C."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Nardone A."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Aplin A.E."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/author | "Erkes D.A."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/pages | "1689"xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/title | "Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation."xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/30976076 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30976076 |
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