| http://purl.uniprot.org/citations/30979869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30979869 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function human variant (SRC-1L1376P), leptin-induced depolarization of Pomc neurons and Pomc expression are significantly reduced, and food intake and body weight are increased. In summary, we demonstrate that SRC-1 modulates the function of hypothalamic Pomc neurons, and suggest that targeting SRC-1 may represent a useful therapeutic strategy for weight loss."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-08737-6"xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "O'Rahilly S."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Liao L."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Tong Q."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Farooqi I.S."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Keogh J.M."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Bochukova E.G."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Henning E."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Mistry V."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Banton M.C."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Hendricks A.E."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "Stadler L.K.J."xsd:string |
| http://purl.uniprot.org/citations/30979869 | http://purl.uniprot.org/core/author | "van der Klaauw A.A."xsd:string |