| http://purl.uniprot.org/citations/30988283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30988283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30988283 | http://www.w3.org/2000/01/rdf-schema#comment | "RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 paradoxically induces these cell death modalities. The molecular switch between RIPK1 pro-survival and pro-death functions remains poorly understood. We identify phosphorylation of RIPK1 on Ser25 by IKKs as a key mechanism directly inhibiting RIPK1 kinase activity and preventing TNF-mediated RIPK1-dependent cell death. Mimicking Ser25 phosphorylation (S > D mutation) protects cells and mice from the cytotoxic effect of TNF in conditions of IKK inhibition. In line with their roles in IKK activation, TNF-induced Ser25 phosphorylation of RIPK1 is defective in TAK1- or SHARPIN-deficient cells and restoring phosphorylation protects these cells from TNF-induced death. Importantly, mimicking Ser25 phosphorylation compromises the in vivo cell death-dependent immune control of Yersinia infection, a physiological model of TAK1/IKK inhibition, and rescues the cell death-induced multi-organ inflammatory phenotype of the SHARPIN-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-09690-0"xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-09690-0"xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Heck A.J.R."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Heck A.J.R."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Savvides S.N."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Savvides S.N."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Rojas-Rivera D."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Rojas-Rivera D."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Giansanti P."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Giansanti P."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Roelandt R."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Roelandt R."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Brodsky I.E."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Brodsky I.E."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Priem D."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Priem D."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Bertrand M.J.M."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Bertrand M.J.M."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Delanghe T."xsd:string |
| http://purl.uniprot.org/citations/30988283 | http://purl.uniprot.org/core/author | "Delanghe T."xsd:string |