| http://purl.uniprot.org/citations/30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30989113 | http://www.w3.org/2000/01/rdf-schema#comment | "How insulin stimulates postprandial uptake of glucose and long-chain fatty acids (LCFAs) into skeletal muscle and the mechanisms by which these events are dampened in diet-induced obesity are incompletely understood. Here, we show that RalGAPα1 is a critical regulator of muscle insulin action and governs both glucose and lipid homeostasis. A high-fat diet increased RalGAPα1 protein but decreased its insulin-responsive Thr735-phosphorylation in skeletal muscle. A RalGAPα1Thr735Ala mutation impaired insulin-stimulated muscle assimilation of glucose and LCFAs and caused metabolic syndrome in mice. In contrast, skeletal muscle-specific deletion of RalGAPα1 improved postprandial glucose and lipid control. Mechanistically, these mutations of RalGAPα1 affected translocation of insulin-responsive glucose transporter GLUT4 and fatty acid translocase CD36 via RalA to affect glucose and lipid homeostasis. These data indicated RalGAPα1 as a dual-purpose target, for which we developed a peptide-blockade for improving muscle insulin sensitivity. Our findings have implications for drug discovery to combat metabolic disorders."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aav4116"xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Ouyang Q."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/author | "Rong P."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/pages | "eaav4116"xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/title | "Targeting RalGAPalpha1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control."xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/30989113 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30989113 |
| http://purl.uniprot.org/citations/30989113 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A087WRZ7-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_E0CZ30-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRX9-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7P2-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7Y4-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P832-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6Q0-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P712-mappedCitation-30989113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/30989113 |