| http://purl.uniprot.org/citations/30992367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/30992367 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyadenylate-binding protein (PABP) stimulates translation termination via interaction of its C-terminal domain with eukaryotic polypeptide chain release factor, eRF3. Additionally, two other proteins, poly(A)-binding protein-interacting proteins 1 and 2 (PAIP1 and PAIP2), bind the same domain of PABP and regulate its translation-related activity. To study the biochemistry of eRF3 and PAIP1/2 competition for PABP binding, we quantified the effects of PAIPs on translation termination in the presence or absence of PABP. Our results demonstrated that both PAIP1 and PAIP2 prevented translation termination at the premature termination codon, by controlling PABP activity. Moreover, PAIP1 and PAIP2 inhibited the activity of free PABP on translation termination in vitro However, after binding the poly(A) tail, PABP became insensitive to suppression by PAIPs and efficiently activated translation termination in the presence of eRF3a. Additionally, we revealed that PAIP1 binds eRF3 in solution, which stabilizes the post-termination complex. These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.006856"xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Ivanov A."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Sokolova E."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Alkalaeva E."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Egorova T."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Shuvalov A."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Shuvalova E."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Bizyaev N."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Shatsky I."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/author | "Terenin I."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/pages | "8630-8639"xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/title | "Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination."xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/30992367 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/30992367 |
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