| http://purl.uniprot.org/citations/31004581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31004581 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating reports suggest that long noncoding RNAs (lncRNAs) play critical roles in the progression of many tumors. In this study, we explored the expression level of lncRNA FOXD2-AS1 in the tumorigenesis of hepatocellular carcinoma (HCC). The data indicated that FOXD2-AS1 expression was increased in HCC specimens and cell lines. Furthermore, aberrant expression was correlated with tumor number and tumor size in HCC patients. Silencing FOXD2-AS1 arrest cell cycle in the G0/G1 phase, inhibited colony formation, cell proliferation and suppressed the in vivo growth of subcutaneous tumors. Our results revealed that FOXD2-AS1 could epigenetically silence CDKN1B by recruiting EZH2 to CDKN1B promoter region. Knocking down CDKN1B could restore the carcinogenic effect of FOXD2-AS1 on HCC. Collectively, our data suggested that FOXD2-AS1 could be new target for therapies or prognostic biomarker in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2019.04.016"xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Xu K."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Zheng S."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Yin S."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Xie H."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/author | "Qian J."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/pages | "198-204"xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/title | "LncRNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma through epigenetically silencing CDKN1B(p27) via EZH2."xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://purl.uniprot.org/core/volume | "380"xsd:string |
| http://purl.uniprot.org/citations/31004581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31004581 |
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