| http://purl.uniprot.org/citations/31005254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31005254 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor kappa B (NF-κB) controls the transcription of various genes in response to immune stimuli. Our previous study revealed that the Droj2/DNAJA3 cochaperone contributes to the NF-κB pathway in Drosophila and humans. In general, the cochaperone is associated with the 70-kDa heat shock protein (HSP70) chaperone and the complex supports the folding of diverse target proteins. The cochaperone/chaperone functions in the NF-κB pathway, however, are not clearly understood. Here, we report that HSP70 proteins are involved in activating canonical NF-κB signaling during immune responses. In human cultured cells, HSP70 inhibitor destabilized the IKKβ/IκBα/NF-κB p65 complex and dampened the phosphorylation of NF-κB p65 in response to flagellin stimulation. We identified HSPA1A and HSPA8 as the HSP70 family proteins that physically interact with DNAJA3, and established their requirement for the phosphorylation of NF-κB p65. Furthermore, as in flies with knockdown of Droj2, flies with knockdown of Hsc70-4, a Drosophila homolog of HSPA8, were more susceptible to infection. Our results suggest that the chaperone/cochaperone complex regulates NF-κB immune signaling in an evolutionarily conserved manner."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.04.077"xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/author | "Fuse N."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/author | "Tamura T."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/author | "Kurata S."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/author | "Kumada K."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/author | "Okamori C."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/pages | "947-951"xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/title | "HSP70/DNAJA3 chaperone/cochaperone regulates NF-kappaB activity in immune responses."xsd:string |
| http://purl.uniprot.org/citations/31005254 | http://purl.uniprot.org/core/volume | "513"xsd:string |
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