| http://purl.uniprot.org/citations/31012334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31012334 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: Alopecia areata (AA) is a non-scarring hair loss with a polymorphous presentation ranging from patchy lesions to involvement of the entire scalp. The disease is the consequence of an autoimmune attack on hair bulbs that results in a premature transition of hair follicles to catagen and telogen. Thus the Wnt/β-catenin signaling pathway that regulates the hair cycling might be involved in the pathogenesis of AA. Genetic variations in the components of Wnt/β-catenin could greatly alter their adaptive mechanisms against an immunologic attack. Objectives: Our aim was to investigate the association between AA and genetic polymorphisms in the TCF7L2 gene, one of the most important components of the Wnt/β-catenin pathway. Methods: This is a case-control study of 145 patients with AA and 152 healthy controls. Genotyping of the TCF7L2 gene (rs7903146) was performed via the ARMS-PCR method (amplification refractory mutation system-polymerase chain reaction). The allele and genotype distribution was compared between the two groups. Results: The frequency of the T allele (0.38 vs. 0.28, odds ratio = 1.56, 95% CI = 1.09-2.17, p = 0.013) and TT + CT genotypes (0.68 vs. 0.53, odds ratio = 1.88, 95% CI = 1.17-3.02, p = 0.008) were significantly higher in AA patients. Conclusions: This study indicates that the TCF7L2 gene variant is associated with AA. Its contribution to disease pathogenesis could either be through a hair cycling defect or dendritic cell dysregulation."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.org/dc/terms/identifier | "doi:10.1080/08820139.2019.1597109"xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Amoli M.M."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Rajabi F."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Robati R.M."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Moravvej H."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Almasi-Nasrabadi M."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/author | "Jabalameli N."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/name | "Immunol Invest"xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/pages | "555-562"xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/title | "The Association between Genetic Variation in Wnt Transcription Factor TCF7L2 (TCF4) and Alopecia Areata."xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/31012334 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31012334 |
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