| http://purl.uniprot.org/citations/31014480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31014480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31014480 | http://www.w3.org/2000/01/rdf-schema#comment | "The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors; however, the mechanisms restricting Prox1 expression and limiting the progenitor pool remain unknown. We identified a zebrafish mutant that displayed premature, expanded, and prolonged lymphatic specification. The gene responsible encodes the regulator of alternative splicing, Nova2. In zebrafish and human endothelial cells, Nova2 selectively regulates pre-mRNA splicing for components of signaling pathways and phosphoproteins. Nova2-deficient endothelial cells display increased Mapk/Erk signaling, and Prox1 expression is dynamically controlled by Erk signaling. We identify a mechanism whereby Nova2-regulated splicing constrains Erk signaling, thus limiting lymphatic progenitor cell specification. This identifies the capacity of a factor that tunes mRNA splicing to control assignment of cell fate during vascular differentiation."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2019.03.017"xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Smith K.A."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Smith K.A."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Baillie G.J."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Baillie G.J."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Harvey N.L."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Harvey N.L."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Muscat G.E.O."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Muscat G.E.O."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Simons C."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Simons C."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Paterson S."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Paterson S."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Hogan B.M."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Hogan B.M."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Bower N.I."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Bower N.I."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Lagendijk A.K."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Lagendijk A.K."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Sutton D.L."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Sutton D.L."xsd:string |
| http://purl.uniprot.org/citations/31014480 | http://purl.uniprot.org/core/author | "Toubia J."xsd:string |