| http://purl.uniprot.org/citations/31015574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31015574 | http://www.w3.org/2000/01/rdf-schema#comment | "Fra-1, a member of the activator protein 1 (AP-1) family, is overexpressed in triple-negative breast cancer (TNBC) and plays crucial roles in tumor growth. Here we report the identification of 118 proteins interacting with endogenous chromatin-bound Fra-1 in TNBC cells, highlighting DDX5 as the most enriched Fra-1-interacting protein. DDX5, a previously unrecognized protein in the Fra-1 transcriptional network, shows extensive overlap with Fra-1 cistrome and transcriptome that are highly associated with the TNBC cell growth. We provide evidence that DDX5 expression enhances Fra-1 transcriptional activity and potentiates Fra-1-driven cell proliferation. Furthermore, we show that the DDX5 target gene signature predicts poor clinical outcome in breast cancer patients. DDX5 protein level was higher in triple-negative basal-like tumors than in non-basal-like tumors, including luminal A, luminal B, and HER2-enriched subtypes. Collectively, by combining proteomic and genomic approaches we reveal a role for DDX5 as a regulatory protein of Fra-1 signaling and suggest DDX5 as a potential therapeutic target for TNBC."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-019-0824-4"xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Sinha I."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Hessling B."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/author | "Haldosen L.A."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/pages | "5725-5738"xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/title | "Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1."xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/31015574 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31015574 |
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