| http://purl.uniprot.org/citations/31022269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31022269 | http://www.w3.org/2000/01/rdf-schema#comment | "The Tec kinases ITK (interleukin-2-inducible T-cell kinase) and RLK (resting lymphocyte kinase) are critical components of the proximal TCR/CD3 signal transduction machinery, and data in mice suggest that ITK negatively modulates regulatory T cell (TREG) differentiation. However, whether Tec kinases modulate TREG development and/or function in human T cells remains unknown. Using a novel self-delivery siRNA platform (sdRNA), we found that ITK knockdown in human primary naïve peripheral blood CD4 T cells increased Foxp3+ expression under both TREG and T helper priming conditions. TREG differentiated under ITK knockdown conditions exhibited enhanced expression of the co-inhibitory receptor PD-1 and were suppressive in a T cell proliferation assay. ITK knockdown decreased IL-17A production in T cells primed under Th17 conditions and promoted Th1 differentiation. Lastly, a dual ITK/RLK Tec kinase inhibitor did not induce Foxp3 in CD4 T cells, but conversely abrogated Foxp3 expression induced by ITK knockdown. Our data suggest that targeting ITK in human T cells may be an effective approach to boost TREG in the context of autoimmune diseases, but concomitant inhibition of other Tec family kinases may negate this effect."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0215963"xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Das A."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Friedman J.R."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Mora J.R."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Mamontov P."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Eberwine R.A."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/author | "Perrigoue J."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/pages | "e0215963"xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/title | "A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation."xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/31022269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31022269 |
| http://purl.uniprot.org/citations/31022269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31022269 |
| http://purl.uniprot.org/uniprot/#_B4E110-mappedCitation-31022269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/#_Q08881-mappedCitation-31022269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/#_Q59F39-mappedCitation-31022269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/#_Q7Z318-mappedCitation-31022269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/Q59F39 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/Q7Z318 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/Q08881 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31022269 |
| http://purl.uniprot.org/uniprot/B4E110 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31022269 |