| http://purl.uniprot.org/citations/31022428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31022428 | http://www.w3.org/2000/01/rdf-schema#comment | "A subset of acute myeloid and lymphoid leukemia cases harbor a t(10;11)(p13;q14) translocation resulting in the CALM-AF10 fusion gene. Standard chemotherapeutic strategies are often ineffective in treating patients with CALM-AF10 fusions. Hence, there is an urgent need to identify molecular pathways dysregulated in CALM-AF10-positive leukemias which may lay the foundation for novel targeted therapies. Here we demonstrate that the Polycomb Repressive Complex 1 gene BMI1 is consistently overexpressed in adult and pediatric CALM-AF10-positive leukemias. We demonstrate that genetic Bmi1 depletion abrogates CALM-AF10-mediated transformation of murine hematopoietic stem and progenitor cells (HSPCs). Furthermore, CALM-AF10-positive murine and human AML cells are sensitive to the small-molecule BMI1 inhibitor PTC-209 as well as to PTC-596, a compound in clinical development that has been shown to result in downstream degradation of BMI1 protein. PTC-596 significantly prolongs survival of mice injected with a human CALM-AF10 cell line in a xenograft assay. In summary, these results validate BMI1 as a bona fide candidate for therapeutic targeting in AML with CALM-AF10 rearrangements."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exphem.2019.04.003"xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Dutta S."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Armstrong S.A."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Deshpande A.J."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Dixon J."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Chen B.R."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Bohlander S.K."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Weetall M."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/author | "Barbosa K."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/name | "Exp Hematol"xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/pages | "42-51.e3"xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/title | "Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1."xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/31022428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31022428 |
| http://purl.uniprot.org/citations/31022428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31022428 |
| http://purl.uniprot.org/uniprot/#_A2ASR5-mappedCitation-31022428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022428 |
| http://purl.uniprot.org/uniprot/#_A2ASR6-mappedCitation-31022428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022428 |
| http://purl.uniprot.org/uniprot/#_A2ASR7-mappedCitation-31022428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022428 |
| http://purl.uniprot.org/uniprot/#_A2ASR8-mappedCitation-31022428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31022428 |