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http://purl.uniprot.org/citations/31033497http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31033497http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Developments in genomic pathology have led to novel molecular classification schemes in gastric cancers. Two of these new subtypes, Epstein-Barr virus (EBV)-associated and microsatellite instability-high (MSI-H), are associated with a dominant T-cell-mediated immune response. The roles of the immune modulators, indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophanyl-tRNA synthetase (WARS), have not been investigated in the context of this classification.

Methods and results

Using in situ hybridization and immunohistochemistry we subclassified 421 primary gastric adenocarcinomas into 5 subtypes, EBV-associated, epithelial to mesenchymal transition, MSI-H, p53-aberrant, and p53-wildtype tumors. Tumor-infiltrative lymphocytes were counted and protein expression of IDO1 and WARS was graded on tissue microarrays of these 421 tumors. High tumor-infiltrative lymphocytes as well as high expression of both IDO1 and WARS was found in EBV and MSI-H tumors. The prognostic effects of IDO1 and WARS expression were tumor subtype dependent. Although high expression levels of IDO1 and WARS were associated with poor prognosis in p53-aberrant, p53-wildtype, and all cancers combined, WARS expression was associated with better prognosis in MSI tumors.

Conclusions

The immunomodulators, IDO1 and WARs, are upregulated and have prognostic significance in EBV-associated and MSI-H tumors. Novel therapies targeting these proteins should be considered in the treatment of these patients."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.org/dc/terms/identifier"doi:10.1097/pai.0000000000000761"xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Lu S."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Kwak Y."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Wang L.J."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Kim W.H."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Resnick M.B."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/author"Lombardo K."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/name"Appl Immunohistochem Mol Morphol"xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/pages"360-368"xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/title"Expression of Indoleamine 2, 3-dioxygenase 1 (IDO1) and Tryptophanyl-tRNA Synthetase (WARS) in Gastric Cancer Molecular Subtypes."xsd:string
http://purl.uniprot.org/citations/31033497http://purl.uniprot.org/core/volume"28"xsd:string
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